| First Author | Moser C | Year | 2021 |
| Journal | Cell Rep | Volume | 35 |
| Issue | 4 | Pages | 109023 |
| PubMed ID | 33909996 | Mgi Jnum | J:319858 |
| Mgi Id | MGI:6717050 | Doi | 10.1016/j.celrep.2021.109023 |
| Citation | Moser C, et al. (2021) Quantification of adipocyte numbers following adipose tissue remodeling. Cell Rep 35(4):109023 |
| abstractText | To analyze the capacity of white and brown adipose tissue remodeling, we developed two mouse lines to label, quantitatively trace, and ablate white, brown, and brite/beige adipocytes at different ambient temperatures. We show here that the brown adipocytes are recruited first and reach a peak after 1 week of cold stimulation followed by a decline during prolonged cold exposure. On the contrary, brite/beige cell numbers plateau after 3 weeks of cold exposure. At thermoneutrality, brown adipose tissue, in spite of being masked by a white-like morphology, retains its brown-like physiology, as Ucp1(+) cells can be recovered immediately upon beta3-adrenergic stimulation. We further demonstrate that the recruitment of Ucp1(+) cells in response to cold is driven by existing adipocytes. In contrast, the regeneration of the interscapular brown adipose tissue following ablation of Ucp1(+) cells is driven by de novo differentiation. |
