| First Author | Bérard AM | Year | 1997 |
| Journal | Nat Med | Volume | 3 |
| Issue | 7 | Pages | 744-9 |
| PubMed ID | 9212100 | Mgi Jnum | J:118355 |
| Mgi Id | MGI:3699468 | Doi | 10.1038/nm0797-744 |
| Citation | Berard AM, et al. (1997) High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase. Nat Med 3(7):744-9 |
| abstractText | A subset of patients with high plasma HDL concentrations have enhanced rather than reduced atherosclerosis. We have developed a new transgenic mouse model overexpressing human lecithin-cholesteryl acyltransferase (LCAT) that has elevated HDL and increased diet-induced atherosclerosis. LCAT transgenic mouse HDLs are abnormal in both composition and function. Liver uptake of [3H]cholesteryl ether incorporated in transgenic mouse HDL was reduced by 41% compared with control HDL, indicating ineffective transport of HDL-cholesterol to the liver and impaired reverse cholesterol transport. Analysis of this LCAT-transgenic mouse model provides in vivo evidence for dysfunctional HDL as a potential mechanism leading to increased atherosclerosis in the presence of high plasma HDL levels. |
