| Primary Identifier | MGI:3696684 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(APOE-ABCA1)30Ssf |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene consists of the human apoE promoter, the human ABCA1 cDNA, the poly(A) signal from the human apoE gene, and the hepatic and macrophage control regions of the apoE/apoC-I locus. Northern blot hybridization analysis and densitometric scanning demonstrated a four-fold increase in encoded mRNA in the liver and a three-fold increase in macrophages. The expressed protein was identified in both mouse liver and macrophage cell extracts by western blotting. |
