| First Author | Huang SS | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 26 | Pages | 6259-68 |
| PubMed ID | 17070806 | Mgi Jnum | J:117713 |
| Mgi Id | MGI:3697285 | Doi | 10.1016/j.febslet.2006.10.028 |
| Citation | Huang SS, et al. (2006) CRSBP-1/LYVE-l-null mice exhibit identifiable morphological and functional alterations of lymphatic capillary vessels. FEBS Lett 580(26):6259-68 |
| abstractText | CRSBP-1, a membrane glycoprotein, can mediate cell-surface retention of secreted growth factors containing CRS motifs such as PDGF-BB. CRSBP-1 has recently been found to be identical to LYVE-1, a specific marker for lymphatic capillary endothelial cells. The in vivo role of CRSBP-1/LYVE-1 is unknown. CRSBP-1-null mice are overtly normal and fertile but exhibit identifiable morphological and functional alterations of lymphatic capillary vessels in certain tissues, marked by the constitutively increased interstitial-lymphatic flow and lack of typical irregularly-shaped lumens. The CRSBP-1 ligands PDGF-BB and HA enhance interstitial-lymphatic flow in wild-type mice but not in CRSBP-1-null animals. |
