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Allele : Htt<tm6Mem> huntingtin; targeted mutation 6, Marcy E MacDonald

Primary Identifier  MGI:3697905 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Htt
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  This allele carries 18 CAG repeat units, with 20 glutamines, in the first exon of the endogenous gene and a floxed neo cassette in the promoter. This allele models the number of CAG repeats found in the human Htt and was found to be a hypomorphic allele, expressing reduced levels of the mutant protein.
  • mutations:
  • Insertion
  • synonyms:
  • Hdh<neoQ20>,
  • Hdh<neoQ20>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

8 Publication categories

Trail: Allele