Primary Identifier | MGI:3697905 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Htt |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | This allele carries 18 CAG repeat units, with 20 glutamines, in the first exon of the endogenous gene and a floxed neo cassette in the promoter. This allele models the number of CAG repeats found in the human Htt and was found to be a hypomorphic allele, expressing reduced levels of the mutant protein. |