| First Author | Hobeika E | Year | 2015 |
| Journal | EMBO J | Volume | 34 |
| Issue | 7 | Pages | 925-39 |
| PubMed ID | 25630702 | Mgi Jnum | J:217519 |
| Mgi Id | MGI:5614303 | Doi | 10.15252/embj.201489732 |
| Citation | Hobeika E, et al. (2015) CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. EMBO J 34(7):925-39 |
| abstractText | The development and function of B lymphocytes is regulated by numerous signaling pathways, some emanating from the B-cell antigen receptor (BCR). The spleen tyrosine kinase (Syk) plays a central role in the activation of the BCR, but less is known about its contribution to the survival and maintenance of mature B cells. We generated mice with an inducible and B-cell-specific deletion of the Syk gene and found that a considerable fraction of mature Syk-negative B cells can survive in the periphery for an extended time. Syk-negative B cells are defective in BCR, RP105 and CD38 signaling but still respond to an IL-4, anti-CD40, CpG or LPS stimulus. Our in vivo experiments show that Syk-deficient B cells require BAFF receptor and CD19/PI3K signaling for their long-term survival. These studies also shed a new light on the signals regulating the maintenance of the normal mature murine B-cell pool. |
