| First Author | Mori T | Year | 2016 |
| Journal | Exp Anim | Volume | 65 |
| Issue | 4 | Pages | 455-463 |
| PubMed ID | 27349442 | Mgi Jnum | J:328568 |
| Mgi Id | MGI:7336260 | Doi | 10.1538/expanim.16-0043 |
| Citation | Mori T, et al. (2016) Generation of a transgenic mouse line for conditional expression of human IL-6. Exp Anim 65(4):455-463 |
| abstractText | IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 transgenic mouse, LGL-IL6, which conditionally expresses human IL-6 by taking advantage of the well-characterized Cre recombinase drivers. |
