| First Author | Yamazaki K | Year | 2003 |
| Journal | J Biol Chem | Volume | 278 |
| Issue | 15 | Pages | 13585-9 |
| PubMed ID | 12604609 | Mgi Jnum | J:82946 |
| Mgi Id | MGI:2656106 | Doi | 10.1074/jbc.C300047200 |
| Citation | Yamazaki K, et al. (2003) Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression. J Biol Chem 278(15):13585-9 |
| abstractText | Elongin A is a transcription elongation factor that increases the overall rate of mRNA chain elongation by RNA polymerase II. To investigate the function of Elongin A in vivo, the two alleles of the Elongin A gene have been disrupted by homologous recombination in murine embryonic stem (ES) cells. The Elongin A-deficient ES cells are viable, but show a slow growth phenotype because they undergo a delayed mitosis. The cDNA microarray and RNase protection assay using the wild-type and Elongin A-deficient ES cells indicate that the expression of only a small subset of genes is affected in the mutant cells. Taken together, our results suggest that Elongin A regulates transcription of a subset but not all of genes and reveal a linkage between Elongin A function and cell cycle progression. |
