| First Author | Carey BW | Year | 2010 |
| Journal | Nat Methods | Volume | 7 |
| Issue | 1 | Pages | 56-9 |
| PubMed ID | 20010831 | Mgi Jnum | J:157298 |
| Mgi Id | MGI:4430597 | Doi | 10.1038/nmeth.1410 |
| Citation | Carey BW, et al. (2010) Single-gene transgenic mouse strains for reprogramming adult somatic cells. Nat Methods 7(1):56-9 |
| abstractText | We report transgenic mouse models in which three or four reprogramming factors are expressed from a single genomic locus using a drug-inducible transgene. Multiple somatic cell types can be directly reprogrammed to generate induced pluripotent stem cells (iPSCs) by culture in doxycycline. Because reprogramming factors are carried on a single polycistronic construct, the mice can be easily maintained, and the transgene can be easily transferred into other genetic backgrounds. |
