| First Author | Stadtfeld M | Year | 2010 |
| Journal | Nat Methods | Volume | 7 |
| Issue | 1 | Pages | 53-5 |
| PubMed ID | 20010832 | Mgi Jnum | J:159350 |
| Mgi Id | MGI:4442338 | Doi | 10.1038/nmeth.1409 |
| Citation | Stadtfeld M, et al. (2010) A reprogrammable mouse strain from gene-targeted embryonic stem cells. Nat Methods 7(1):53-5 |
| abstractText | The derivation of induced pluripotent stem cells (iPSCs) usually involves the viral introduction of reprogramming factors into somatic cells. Here we used gene targeting to generate a mouse strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the induction of pluripotency in various somatic cell types. As these 'reprogrammable mice' can be easily bred, they are a useful tool to study the mechanisms underlying cellular reprogramming. |
