| Primary Identifier | MGI:3703793 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Humanized sequence, Inducible, Inserted expressed sequence | Gene | Tg(tetO-BMPR2*T504)1Jwst |
| Strain of Origin | FVB/N | Induced With | doxycycline/tetracycline |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Seven copies of the tetracycline responsive element and the CMV minimal promoter were used to drive the expression of a dominant-negative mutant BMPR2. The BMPR2 mutation is an insertion of a T at base 504 in the kinase (4th) domain of the protein, resulting in a premature stop 18 amino acids into the kinase domain. These transgenic mice were crossed to Tg(Tagln-rtTA)E1Jwst mice to obtain mice with inducible, muscle-specific expression of dominant-negative BMPR2. |
