Primary Identifier | MGI:3709262 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(CD19-BTK*K430R)XK24Rwhe |
Strain of Origin | FVB | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A composite fragment composed of 400bp from exons 1-3 of a BTK cDNA as well as 27kb genomic fragment containing exons 3-19 of BTK was placed under the control of the promoter region of human CD19. A K430R mutation was introduced into this construct by double stranded site-directed mutagenesis. |