| First Author | Cunha C | Year | 2009 |
| Journal | Neurobiol Dis | Volume | 33 |
| Issue | 3 | Pages | 358-68 |
| PubMed ID | 19095063 | Mgi Jnum | J:146304 |
| Mgi Id | MGI:3837250 | Doi | 10.1016/j.nbd.2008.11.004 |
| Citation | Cunha C, et al. (2009) Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments. Neurobiol Dis 33(3):358-68 |
| abstractText | In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the alphaCaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice and their WT littermates were examined with a battery of behavioral tests, in order to evaluate motor coordination, learning, short and long-term memory formation. Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation. |
