| First Author | Dewey JB | Year | 2018 |
| Journal | Cell Rep | Volume | 23 |
| Issue | 10 | Pages | 2915-2927 |
| PubMed ID | 29874579 | Mgi Jnum | J:270857 |
| Mgi Id | MGI:6278799 | Doi | 10.1016/j.celrep.2018.05.024 |
| Citation | Dewey JB, et al. (2018) Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea. Cell Rep 23(10):2915-2927 |
| abstractText | The stereociliary bundles of cochlear hair cells convert mechanical vibrations into the electrical signals required for auditory sensation. While the stiffness of the bundles strongly influences mechanotransduction, its influence on the vibratory response of the cochlear partition is unclear. To assess this, we measured cochlear vibrations in mutant mice with reduced bundle stiffness or with a tectorial membrane (TM) that is detached from the sensory epithelium. We found that reducing bundle stiffness decreased the high-frequency extent and sharpened the tuning of vibratory responses obtained postmortem. Detaching the TM further reduced the high-frequency extent of the vibrations but also lowered the partition's resonant frequency. Together, these results demonstrate that the bundle's stiffness and attachment to the TM contribute to passive longitudinal coupling in the cochlea. We conclude that the stereociliary bundles and TM interact to facilitate passive-wave propagation to more apical locations, possibly enhancing active-wave amplification in vivo. |
