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Allele : Tg(Pax8-rtTA2S*M2)1Koes transgene insertion 1, Robert Koesters
Primary Identifier  MGI:3709326 Allele Type  Transgenic
Attribute String  Transactivator Gene  Tg(Pax8-rtTA2S*M2)1Koes
Strain of Origin  (C57BL/6 x DBA)F2 Is Recombinase  false
Is Wild Type  false
molecularNote  The Pax8-rtTA construct contains an optimized rtTA variant (rtTA2s-M2) cDNA and SV40 polyA sequence replaced at the endogenous ATG translational start site of a murine Pax8 sequence. The rtTA2S*M2 variant contains 5 amino acid changes in the TetR moiety (S12G, E19G, A56P, D148E, and H179R) and a synthetic optimized transactivating domain, resulting in reduced basal activity and enhanced doxycycline sensitivity compared to wild-type rtTA.
  • mutations:
  • Insertion
  • synonyms:
  • Pax8-rtTA,
  • Pax8-rtTA
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Trail: Allele

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Trail: Allele




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