| First Author | Yang S | Year | 2021 |
| Journal | Cell Rep | Volume | 36 |
| Issue | 6 | Pages | 109502 |
| PubMed ID | 34380037 | Mgi Jnum | J:323532 |
| Mgi Id | MGI:6765705 | Doi | 10.1016/j.celrep.2021.109502 |
| Citation | Yang S, et al. (2021) An mPOA-ARC(AgRP) pathway modulates cold-evoked eating behavior. Cell Rep 36(6):109502 |
| abstractText | Enhanced appetite occurs as a means of behavioral thermoregulation at low temperature. Neural circuitry mediating this crosstalk between behavioral thermoregulation and energy homeostasis remains to be elucidated. We find that the hypothalamic orexigenic agouti-related neuropeptide (AgRP) neurons in the arcuate nucleus (ARC) are profoundly activated by cold exposure. The calcium signals in ARC(AgRP) neurons display an immediate-response pattern in response to cold stimulation. Cold-responsive neurons in the medial preoptic area (mPOA) make excitatory synapses onto ARC(AgRP) neurons. Inhibition of either ARC(AgRP) neurons or ARC-projecting mPOA neurons attenuates cold-evoked feeding, while activation of the mPOA-to-ARC projection increases food intake. These findings reveal an mPOA-ARC(AgRP) neural pathway that modulates cold-evoked feeding behavior. |
