| First Author | Yamashita R | Year | 2009 |
| Journal | Dev Dyn | Volume | 238 |
| Issue | 4 | Pages | 993-1000 |
| PubMed ID | 19301403 | Mgi Jnum | J:147036 |
| Mgi Id | MGI:3839156 | Doi | 10.1002/dvdy.21900 |
| Citation | Yamashita R, et al. (2009) Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice. Dev Dyn 238(4):993-1000 |
| abstractText | Leucine-rich repeat (LRR) -containing G protein coupled receptor (LGR) family members are characterized by the presence of a seven-transmembrane domain and LRR motifs. We describe a new function for Lgr4 in the development of the gall bladder and cystic duct and in the epithelium-mesenchyme interaction. Lgr4 expression was observed in the gall bladder epithelium when the gall bladder primordium elongated ventrally. Although Lgr4 hypomorphic mutant (Lgr4(Gt/Gt)) embryos developed a normal gall bladder bud at embryonic day (E) 10.25, no further elongation was observed at later stages. At E12.5, the mesenchyme surrounding the gall bladder had completely disappeared in Lgr4(Gt/Gt) embryos, while the gall bladder remained unelongated. Neighboring tissues such as liver and pancreas were unaffected, as revealed by expression of marker genes. This is the first report of a mutant mouse that lacks a gall bladder and cystic duct without affecting the other tissues that derive from the same hepatic diverticulum. Developmental Dynamics 238:993-1000, 2009. (c) 2009 Wiley-Liss, Inc. |
