| First Author | Zhou H | Year | 2014 |
| Journal | Elife | Volume | 3 |
| PubMed ID | 24876128 | Mgi Jnum | J:228546 |
| Mgi Id | MGI:5707571 | Doi | 10.7554/eLife.02811 |
| Citation | Zhou H, et al. (2014) TAF7L modulates brown adipose tissue formation. Elife 3 |
| abstractText | Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differentiation. In this study, we show that TAF7L also serves as a molecular switch between brown fat and muscle lineages in vivo and in vitro. In adipose tissue, TAF7L-containing TFIID complexes associate with PPARgamma to mediate DNA looping between distal enhancers and core promoter elements. Our findings suggest that the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during BAT lineage specification. |
