| First Author | Thai TH | Year | 2007 |
| Journal | Science | Volume | 316 |
| Issue | 5824 | Pages | 604-8 |
| PubMed ID | 17463289 | Mgi Jnum | J:121084 |
| Mgi Id | MGI:3709222 | Doi | 10.1126/science.1141229 |
| Citation | Thai TH, et al. (2007) Regulation of the germinal center response by microRNA-155. Science 316(5824):604-8 |
| abstractText | MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo. |
