| First Author | Clare S | Year | 2013 |
| Journal | Infect Immun | Volume | 81 |
| Issue | 3 | Pages | 723-32 |
| PubMed ID | 23264052 | Mgi Jnum | J:193043 |
| Mgi Id | MGI:5467454 | Doi | 10.1128/IAI.00969-12 |
| Citation | Clare S, et al. (2013) Enhanced Susceptibility to Citrobacter rodentium Infection in MicroRNA-155-Deficient Mice. Infect Immun 81(3):723-32 |
| abstractText | MicroRNAs (miRNAs) are small noncoding molecules that control gene expression posttranscriptionally, with microRNA-155 (miR-155) one of the first to be implicated in immune regulation. Here, we show that miR-155-deficient mice are less able to eradicate a mucosal Citrobacter rodentium infection than wild-type C57BL/6 mice. miR-155-deficient mice exhibited prolonged colonization associated with a higher C. rodentium burden in gastrointestinal tissue and spread into systemic tissues. Germinal center formation and humoral immune responses against C. rodentium were severely impaired in infected miR-155-deficient mice. A similarly susceptible phenotype was observed in muMT mice reconstituted with miR-155-deficient B cells, indicating that miR-155 is required intrinsically for mediating protection against this predominantly luminal bacterial pathogen. |
