| First Author | Ferguson SM | Year | 2007 |
| Journal | Science | Volume | 316 |
| Issue | 5824 | Pages | 570-4 |
| PubMed ID | 17463283 | Mgi Jnum | J:121111 |
| Mgi Id | MGI:3709249 | Doi | 10.1126/science.1140621 |
| Citation | Ferguson SM, et al. (2007) A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. Science 316(5824):570-4 |
| abstractText | Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity. |
