| First Author | Aly M | Year | 2007 |
| Journal | Genes Immun | Volume | 8 |
| Issue | 3 | Pages | 193-204 |
| PubMed ID | 17287827 | Mgi Jnum | J:121574 |
| Mgi Id | MGI:3710680 | Doi | 10.1038/sj.gene.6364374 |
| Citation | Aly M, et al. (2007) Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis. Genes Immun 8(3):193-204 |
| abstractText | The pathogenesis of viral myocarditis is a multifactorial process involving host genetics, viral genetics and the environment in which they interact. We have used a model of infection with coxsackievirus B3 (CVB3) to characterize the contribution of host genetics to viral myocarditis in mice of different genetic backgrounds but with a common H2 haplotype: A/J and B10.A-H2(a). Here we have used Evans blue dye as a quantitative biomarker for susceptibility to CVB3-induced myocarditis in addition to histopathological semiquantitative measures. We have found evidence of linkage between susceptibility to viral myocarditis and three loci. A locus on chromosome 1 centered on D1Mit200 was linked to sarcolemmal disruption in males (P=0.00005), a second locus on chromosome 4 centered on D4Mit81 was also linked to sarcolemmal disruption in males (P=0.0022). A third locus on distal chromosome 3 centered on D3Mit19 was linked to myocardial infiltration, with a logarithm of odds (LOD) score of 4.7 (P=0.0045), as well as sarcolemmal disruption in females (P=0.0015). These results provide strong evidence for the presence of loci contributing to the susceptibility of mice to viral myocarditis. |
