| First Author | Pichlmair A | Year | 2004 |
| Journal | J Virol | Volume | 78 |
| Issue | 20 | Pages | 11422-4 |
| PubMed ID | 15452266 | Mgi Jnum | J:93773 |
| Mgi Id | MGI:3505669 | Doi | 10.1128/JVI.78.20.11422-11424.2004 |
| Citation | Pichlmair A, et al. (2004) Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice. J Virol 78(20):11422-4 |
| abstractText | The Thogoto virus ML protein suppresses interferon synthesis in infected cells. Nevertheless, a virus mutant lacking ML remained highly pathogenic in standard laboratory mice. It was strongly attenuated, however, in mice carrying the interferon-responsive Mx1 gene found in wild mice, demonstrating that enhanced interferon synthesis is protective only if appropriate antiviral effector molecules are present. Our study shows that the virulence-enhancing effects of some viral interferon antagonists may escape detection in conventional animal models. |
