| First Author | Winder DG | Year | 1998 |
| Journal | Cell | Volume | 92 |
| Issue | 1 | Pages | 25-37 |
| PubMed ID | 9489697 | Mgi Jnum | J:77291 |
| Mgi Id | MGI:2181319 | Doi | 10.1016/s0092-8674(00)80896-x |
| Citation | Winder DG, et al. (1998) Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell 92(1):25-37 |
| abstractText | To investigate the role of phosphatases in synaptic plasticity using genetic approaches, we generated transgenic mice that overexpress a truncated form of calcineurin under the control of the CaMKIIalpha promoter. Mice expressing this transgene show increased calcium-dependent phosphatase activity in the hippocampus. Physiological studies of these mice and parallel pharmacological experiments in wild-type mice reveal a novel, intermediate phase of LTP (I-LTP) in the CA1 region of the hippocampus. This intermediate phase differs from E-LTP by requiring multiple trains for induction and in being dependent on PKA. It differs from L-LTP in not requiring new protein synthesis. These data suggest that calcineurin acts as an inhibitory constraint on I-LTP that is relieved by PKA. This inhibitory constraint acts as a gate to regulate the synaptic induction of L-LTP. |
