Primary Identifier | MGI:3716756 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Ar |
Transmission | Germline | Strain of Origin | 129X1/SvJ |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Cre-mediated recombination in the germline resulted in the loss of exon 3, which encodes the second zinc finger of the DNA-binding domain. This deletion has been designed to retain the normal reading frame so that the mutant AR can bind ligand but is unable to bind DNA and regulate target gene transcription. |