| First Author | Gokozan HN | Year | 2016 |
| Journal | J Comp Neurol | Volume | 524 |
| Issue | 6 | Pages | 1259-69 |
| PubMed ID | 26400711 | Mgi Jnum | J:251977 |
| Mgi Id | MGI:6102225 | Doi | 10.1002/cne.23903 |
| Citation | Gokozan HN, et al. (2016) Area postrema undergoes dynamic postnatal changes in mice and humans. J Comp Neurol 524(6):1259-69 |
| abstractText | The postnatal period in mammals represents a developmental epoch of significant change in the autonomic nervous system (ANS). This study focuses on postnatal development of the area postrema, a crucial ANS structure that regulates temperature, breathing, and satiety, among other activities. We find that the human area postrema undergoes significant developmental changes during postnatal development. To characterize these changes further, we used transgenic mouse reagents to delineate neuronal circuitry. We discovered that, although a well-formed ANS scaffold exists early in embryonic development, the area postrema shows a delayed maturation. Specifically, postnatal days 0-7 in mice show no significant change in area postrema volume or synaptic input from PHOX2B-derived neurons. In contrast, postnatal days 7-20 show a significant increase in volume and synaptic input from PHOX2B-derived neurons. We conclude that key ANS structures show unexpected dynamic developmental changes during postnatal development. These data provide a basis for understanding ANS dysfunction and disease predisposition in premature and postnatal humans. |
