| First Author | Krotenberg Garcia A | Year | 2021 |
| Journal | Cell Rep | Volume | 36 |
| Issue | 1 | Pages | 109307 |
| PubMed ID | 34233177 | Mgi Jnum | J:353220 |
| Mgi Id | MGI:6874554 | Doi | 10.1016/j.celrep.2021.109307 |
| Citation | Krotenberg Garcia A, et al. (2021) Active elimination of intestinal cells drives oncogenic growth in organoids. Cell Rep 36(1):109307 |
| abstractText | Competitive cell interactions play a crucial role in quality control during development and homeostasis. Here, we show that cancer cells use such interactions to actively eliminate wild-type intestine cells in enteroid monolayers and organoids. This apoptosis-dependent process boosts proliferation of intestinal cancer cells. The remaining wild-type population activates markers of primitive epithelia and transits to a fetal-like state. Prevention of this cell-state transition avoids elimination of wild-type cells and, importantly, limits the proliferation of cancer cells. Jun N-terminal kinase (JNK) signaling is activated in competing cells and is required for cell-state change and elimination of wild-type cells. Thus, cell competition drives growth of cancer cells by active out-competition of wild-type cells through forced cell death and cell-state change in a JNK-dependent manner. |
