| First Author | Steffen J | Year | 2022 |
| Journal | Cell Rep | Volume | 38 |
| Issue | 13 | Pages | 110564 |
| PubMed ID | 35354032 | Mgi Jnum | J:325712 |
| Mgi Id | MGI:7286515 | Doi | 10.1016/j.celrep.2022.110564 |
| Citation | Steffen J, et al. (2022) Type 1 innate lymphoid cells regulate the onset of Toxoplasma gondii-induced neuroinflammation. Cell Rep 38(13):110564 |
| abstractText | Cerebral infections are restrained by a complex interplay of tissue-resident and recruited peripheral immune cells. Whether innate lymphoid cells (ILCs) are involved in the orchestration of the neuroinflammatory dynamics is not fully understood. Here, we demonstrate that ILCs accumulate in the cerebral parenchyma, the choroid plexus, and the meninges in the onset of cerebral Toxoplasma gondii infection. Antibody-mediated depletion of conventional natural killer (cNK) cells and ILC1s in the early stage of infection results in diminished cytokine and chemokine expression and increased cerebral parasite burden. Using cNK- and ILC1-deficient murine models, we demonstrate that exclusively the lack of ILC1s affects cerebral immune responses. In summary, our results provide evidence that ILC1s are an early source of IFN-gamma and TNF in response to cerebral T. gondii infection, thereby inducing host defense factors and initiating the development of a neuroinflammatory response. |
