| First Author | Labelle M | Year | 2011 |
| Journal | Cancer Cell | Volume | 20 |
| Issue | 5 | Pages | 576-90 |
| PubMed ID | 22094253 | Mgi Jnum | J:178954 |
| Mgi Id | MGI:5300667 | Doi | 10.1016/j.ccr.2011.09.009 |
| Citation | Labelle M, et al. (2011) Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20(5):576-90 |
| abstractText | Interactions of cancer cells with the primary tumor microenvironment are important determinants of cancer progression toward metastasis but it is unknown whether additional prometastatic signals are provided during the intravascular transit to the site of metastasis. Here, we show that platelet-tumor cell interactions are sufficient to prime tumor cells for subsequent metastasis. Platelet-derived TGFbeta and direct platelet-tumor cell contacts synergistically activate the TGFbeta/Smad and NF-kappaB pathways in cancer cells, resulting in their transition to an invasive mesenchymal-like phenotype and enhanced metastasis in vivo. Inhibition of NF-kappaB signaling in cancer cells or ablation of TGFbeta1 expression solely in platelets protects against lung metastasis in vivo. Thus, cancer cells rely on platelet-derived signals outside of the primary tumor for efficient metastasis. |
