| Primary Identifier | MGI:3720083 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(APP-App*R609D*K612E)7Vln |
| Strain of Origin | FVB | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Murine App cDNA containing R609D and K612E mutations was inserted downstream of the human APP gene promoter with a beta-globin intron interspersed. The construct was microinjected into 1.5-day-old pre-nuclear embryos from FVB females. Transgene expression in the brain was verified by RT-PCR. Expression was low compared to endogenous App levels in the mouse brain. |
