Primary Identifier | MGI:3720741 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Ctla4 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The human CTLA4 exons 2 and 3 were inserted into the locus to replace endogenous exons 2 and 3. These exons encode the extracellular and transmembrane domains. A floxed neo was subsequently removed via transient cre expression. |