| First Author | Rodrigues E-Lacerda R | Year | 2024 |
| Journal | iScience | Volume | 27 |
| Issue | 11 | Pages | 111130 |
| PubMed ID | 39507249 | Mgi Jnum | J:358171 |
| Mgi Id | MGI:7778997 | Doi | 10.1016/j.isci.2024.111130 |
| Citation | Rodrigues E-Lacerda R, et al. (2024) NOD2 protects against allergic lung inflammation in obese female mice. iScience 27(11):111130 |
| abstractText | Obesity is associated with compartmentalized changes in immune responses that can be protective or pathogenic. It has been proposed that obesity-related changes in the microbiota influence allergic lung inflammation. We hypothesized that sensors of the bacterial cell wall influenced allergenic lung inflammation during obesity. Ovalbumin (OVA)-induced lung inflammation was similar in female Nod1(-/-) and wild-type mice during high-fat-diet-induced obesity, but allergic lung inflammation was higher in obese, high-fat-diet-fed female Nod2(-/-) mice. Obese Nod2(-/-) mice had higher inflammatory cell infiltration in the bronchial alveolar lavage (BAL) and lungs, pulmonary fibrosis, mucus levels, hypertrophy and hyperplasia of goblet cells, M2 alveolar macrophage infiltration, interleukin-4 (IL-4), IL-5, IL-6, and lower CXCL1 and IL-22. Therefore, Nod2 protects against excessive lung inflammation and is a bacterial sensor that relays protective responses to allergenic lung inflammation in obese female mice. |
