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Transgene : Tg(DMD-APP*)7Neve transgene insertion 7, Rachel L Neve
Primary Identifier  MGI:3720647 Organism  mouse, laboratory
Chromosome  UN Mgi Type  transgene
description  PHENOTYPE: Transgenic mice express the C100 fragment of APP at hign levels in the brain. Amyloid peptide (AB1-42 accumulation is detected in neurons, primarily in the hippocampus at ~ 4 months of age. Animals start to develop neurodegeneration at ~1 year, with severe neuropathology evident at 18-24 months. [provided by MGI curators]
  • synonyms:
  • BetaAPP-C104,
  • transgene insertion 7, Rachel L Neve,
  • Tg(DMD-APP*)7Neve,
  • APP-C100
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