| First Author | Tacconi C | Year | 2021 |
| Journal | Cell Rep | Volume | 35 |
| Issue | 2 | Pages | 108993 |
| PubMed ID | 33852863 | Mgi Jnum | J:306563 |
| Mgi Id | MGI:6716735 | Doi | 10.1016/j.celrep.2021.108993 |
| Citation | Tacconi C, et al. (2021) CD169(+) lymph node macrophages have protective functions in mouse breast cancer metastasis. Cell Rep 35(2):108993 |
| abstractText | Although the contribution of macrophages to metastasis is widely studied in primary tumors, the involvement of macrophages in tumor-draining lymph nodes (LNs) in this process is less clear. We find CD169(+) macrophages as the predominant macrophage subtype in naive LNs, which undergo proliferative expansion in response to tumor stimuli. CD169(+) LN macrophage depletion, using an anti-CSF-1R antibody or clodronate-loaded liposomes, leads to increased metastatic burden in two mouse breast cancer models. The expansion of CD169(+) macrophages is tightly connected to B cell expansion in tumor-draining LNs, and B cell depletion abrogates the effect of CD169(+) macrophage absence on metastasis, indicating that the CD169(+) macrophage anti-metastatic effects require B cell presence. These results reveal a protective role of CD169(+) LN macrophages in breast cancer metastasis and raise caution for the use of drugs aiming at the depletion of tumor-associated macrophages, which might simultaneously deplete macrophages in tumor-draining LNs. |
