| First Author | Alvarado JA | Year | 2021 |
| Journal | J Comp Neurol | Volume | 529 |
| Issue | 7 | Pages | 1442-1455 |
| PubMed ID | 32939774 | Mgi Jnum | J:307086 |
| Mgi Id | MGI:6711008 | Doi | 10.1002/cne.25029 |
| Citation | Alvarado JA, et al. (2021) Developmental distribution of primary cilia in the retinofugal visual pathway. J Comp Neurol 529(7):1442-1455 |
| abstractText | The mammalian visual system is composed of circuitry connecting sensory input from the retina to the processing core of the visual cortex. The two main retinorecipient brain targets, the superior colliculus (SC) and dorsal lateral geniculate nucleus (dLGN), bridge retinal input and visual output. The primary cilium is a conserved organelle increasingly viewed as a critical sensor for the regulation of developmental and homeostatic pathways in most mammalian cell types. Moreover, cilia have been described as crucial for neurogenesis, neuronal maturation, and survival in the cortex and retina. However, cilia in the visual relay center remain to be fully described. In this study, we characterized the ciliation profile of the SC and dLGN and found that the overall number of ciliated cells declined during development. Interestingly, shorter ciliated cells in both regions were identified as neurons, whose numbers remained stable over time, suggesting that cilia retention is a critical feature for optimal neuronal function in SC and dLGN. Our study suggests that primary cilia are important for neuronal maturation and function in cells of the SC and dLGN. |
