| First Author | Tabilas C | Year | 2019 |
| Journal | J Immunol | Volume | 203 |
| Issue | 10 | Pages | 2571-2576 |
| PubMed ID | 31597706 | Mgi Jnum | J:280949 |
| Mgi Id | MGI:6370332 | Doi | 10.4049/jimmunol.1900426 |
| Citation | Tabilas C, et al. (2019) Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8(+) T Cells in Early Life. J Immunol 203(10):2571-2576 |
| abstractText | Neonates often develop poor immunity against intracellular pathogens. Because CD8(+) T cells are essential for eliminating infectious agents, it is crucial to understand why they behave differently in early life. Previous studies in mice have demonstrated that neonatal CD8(+) T cells fail to form memory because of an intrinsic propensity to differentiate into short-lived effectors. However, the underlying mechanisms remain undefined. We now show that neonatal CD8(+) T cells exhibit higher glycolytic activity than adult CD8(+) T cells postinfection, which may be due to age-related differences in Lin28b expression. Importantly, when glycolysis is pharmacologically inhibited, the impaired formation of neonatal memory CD8(+) T cells can be restored. Collectively, these data suggest that neonatal CD8(+) T cells are inherently biased toward undergoing glycolytic metabolism postinfection, which compromises their ability to develop into memory CD8(+) T cells in early life. |
