| First Author | Nechiporuk T | Year | 2013 |
| Journal | Dev Biol | Volume | 377 |
| Issue | 2 | Pages | 375-84 |
| PubMed ID | 23466739 | Mgi Jnum | J:196288 |
| Mgi Id | MGI:5487693 | Doi | 10.1016/j.ydbio.2013.02.019 |
| Citation | Nechiporuk T, et al. (2013) Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis. Dev Biol 377(2):375-84 |
| abstractText | Cell polarity plays an important role in tissue morphogenesis; however, the mechanisms of polarity and their role in mammalian development are still poorly understood. We show here that membrane-associated guanylate kinase protein Dlg5 is required for proper branching morphogenesis and progenitor differentiation in mammalian lung. We found that during lung development Dlg5 functions as an apical-basal polarity protein, which is necessary for the apical maintenance of atypical protein kinase C (aPKC). These results identify Dlg5 as a regulator of apical polarity complexes and uncover the critical function of Dlg5 in branching morphogenesis and differentiation of lung progenitor cells. |
