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Allele : Tg(MMTV-neu/OT-I/OT-II)CBnel transgene insertion C, Brad Nelson
Primary Identifier  MGI:3761163 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(MMTV-neu/OT-I/OT-II)CBnel
Strain of Origin  C57BL/6 Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene construct was designed to tag T cell receptor-recognized ovalbumin epitopes SIIFEKL (CD8+, OT-1) and ISQAVHAAHAEINEAGR (CD4+, OT-II)with the rat Erbb2/HER-2/neu oncogene under the control of an MMTV promoter creating a fusion protein (termed neuOT-I/OT-II). The vector was injected into C57BL/6 oocytes. Line C was selected for further studies based on mammary-specific expression and favorable tumor latency and frequency.
  • mutations:
  • Insertion
  • synonyms:
  • MMTV-HER2/Neu-Ovalbumin,
  • MMTV-HER2/Neu-Ovalbumin,
  • neu<OT-I/OT-II>,
  • neu<OT-I/OT-II>
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1 Feature

Trail: Allele

Genome

1 Expresses

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Driven By

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Trail: Allele




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