Primary Identifier | MGI:3759305 | Allele Type | Transgenic |
Attribute String | Inducible, Recombinase | Gene | Tg(Camk2a-cre/ERT2)2Gsc |
Strain of Origin | FVB/N | Induced With | tamoxifen |
Is Recombinase | true | Is Wild Type | false |
description | Three lines were created (lines 1, 2 and 3) with 1, 2 and 4 copy numbers of the transgene, respectively. Line 2 was choosen as the representative line because while copy number affects the level of expression similar phenotypes are produced and the majority of the reporting in J:125230 focuses on line 2. |
molecularNote | The Camk2a promoter was used to drive expression of a cre and human estrogen receptor fusion (cre/ESR1). Expression is inducible by tamoxifen and localizes to the neurons of the adult forebrain. |