| First Author | Kim SJ | Year | 2012 |
| Journal | Immune Netw | Volume | 12 |
| Issue | 6 | Pages | 253-60 |
| PubMed ID | 23396851 | Mgi Jnum | J:347186 |
| Mgi Id | MGI:6511427 | Doi | 10.4110/in.2012.12.6.253 |
| Citation | Kim SJ, et al. (2012) alpha-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation. Immune Netw 12(6):253-60 |
| abstractText | alpha-Mangostin is a xanthon derivative contained in the fruit hull of mangosteen (Garcinia mangostana L.), and the administration of alpha-Mangostin inhibited the growth of transplanted colon cancer, Her/CT26 cells which expressed Her-2/neu as tumor antigen. Although alpha-Mangostin was reported to have inhibitory activity against sarco/endoplasmic reticulum Ca(2+) ATPase like thapsigargin, it showed different activity for autophagy regulation. In the current study, we found that alpha-Mangostin induced autophagy activation in mouse intestinal epithelial cells, as GFP-LC3 transgenic mice were orally administered with 20 mg/kg of alpha-Mangostin daily for three days. However, the activation of autophagy by alpha-Mangostin did not significantly increase OVA-specific T cell proliferation. As we assessed ER stress by using XBP-1 reporter system and phosphorylation of eIF2alpha, thapsigargin-induced ER stress was significantly reduced by alpha-Mangostin. However, coadministration of thapsigargin with alpha-Mangostin completely blocked the antitumor activity of alpha-Mangostin, suggesting ER stress with autophagy blockade accelerated tumor growth in mouse colon cancer model. Thus the antitumor activity of alpha-Mangostin can be ascribable to the autophagy activation rather than ER stress induction. |
