| First Author | Nakagawa I | Year | 2004 |
| Journal | Science | Volume | 306 |
| Issue | 5698 | Pages | 1037-40 |
| PubMed ID | 15528445 | Mgi Jnum | J:347182 |
| Mgi Id | MGI:6511495 | Doi | 10.1126/science.1103966 |
| Citation | Nakagawa I, et al. (2004) Autophagy defends cells against invading group A Streptococcus. Science 306(5698):1037-40 |
| abstractText | We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens. |
