| First Author | Tao H | Year | 2021 |
| Journal | Front Immunol | Volume | 12 |
| Pages | 623280 | PubMed ID | 33732245 |
| Mgi Jnum | J:316686 | Mgi Id | MGI:6807436 |
| Doi | 10.3389/fimmu.2021.623280 | Citation | Tao H, et al. (2021) Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor alpha Chain Foster Local Environment for Type 1 Innate Like T Cell Development. Front Immunol 12:623280 |
| abstractText | Expression of tissue-restricted antigens (TRAs) in thymic epithelial cells (TECs) ensures negative selection of highly self-reactive T cells to establish central tolerance. Whether some of these TRAs could exert their canonical biological functions to shape thymic environment to regulate T cell development is unclear. Analyses of publicly available databases have revealed expression of transcripts at various levels of many cytokines and cytokine receptors such as IL-15, IL-15Ralpha, IL-13, and IL-23a in both human and mouse TECs. Ablation of either IL-15 or IL-15Ralpha in TECs selectively impairs type 1 innate like T cell, such as iNKT1 and gammadeltaT1 cell, development in the thymus, indicating that TECs not only serve as an important source of IL-15 but also trans-present IL-15 to ensure type 1 innate like T cell development. Because type 1 innate like T cells are proinflammatory, our data suggest the possibility that TEC may intrinsically control thymic inflammatory innate like T cells to influence thymic environment. |
