| First Author | Liu JY | Year | 2023 |
| Journal | Neurosci Lett | Volume | 807 |
| Pages | 137278 | PubMed ID | 37116573 |
| Mgi Jnum | J:341770 | Mgi Id | MGI:7485629 |
| Doi | 10.1016/j.neulet.2023.137278 | Citation | Liu JY, et al. (2023) Inward rectifying K(ir)4.1 channels regulate oligodendrocyte precursor cell differentiation and CNS myelination in vivo. Neurosci Lett 807:137278 |
| abstractText | The functions of K(ir)4.1 in oligodendrocyte development have been in controversial. We recently reported that inhibiting K(ir)4.1 impeded oligodendrocyte precursor cell (OPC) differentiation and oligodendrocyte (OL) maturation, due to K(ir)4.1 altering intracellular pH of OPCs through Na(+)/H(+) exchangers. However, our conclusion was limited by in vitro observation, thereby it becomes necessary to seek in vivo evidence to determine the roles of K(ir)4.1 on OPC development and CNS myelination. Here, we used Olig1-Cre to knockout K(ir)4.1 in OPCs from the early developmental stage. We found that the cell-specific deletion of K(ir)4.1 significantly impeded OPC differentiation and reduced the number of mature OLs in the cerebral cortex and the corpus callosum. Hence, our in vivo evidence supports that K(ir)4.1 can regulate OPC differentiation and is essential to CNS myelination. |
