| First Author | Obhrai JS | Year | 2008 |
| Journal | J Invest Dermatol | Volume | 128 |
| Issue | 8 | Pages | 1950-5 |
| PubMed ID | 18337832 | Mgi Jnum | J:141614 |
| Mgi Id | MGI:3819034 | Doi | 10.1038/jid.2008.52 |
| Citation | Obhrai JS, et al. (2008) Langerhans cells are not required for efficient skin graft rejection. J Invest Dermatol 128(8):1950-5 |
| abstractText | The mechanism of skin allograft rejection has been thought to require presentation of graft antigen by resident epidermal Langerhans cells (LCs). We have previously engineered mice that have a selective and constitutive absence of epidermal LCs. By using donor skin from these LC-deficient mice, we show that LCs are not required for rejection of major (FVB --> B6) or minor (H-Y, male --> female on B6 background) antigen-mismatched skin grafts. On the FVB background, where H-Y mismatched grafts are normally maintained indefinitely, grafts lacking LCs are efficiently rejected. Thus, LCs in the donor graft are required for long-term skin engraftment, which supports a regulatory role for LCs in skin graft acceptance. |
