| First Author | Luo Y | Year | 2020 |
| Journal | Exp Cell Res | Volume | 392 |
| Issue | 2 | Pages | 112003 |
| PubMed ID | 32278689 | Mgi Jnum | J:293265 |
| Mgi Id | MGI:6445758 | Doi | 10.1016/j.yexcr.2020.112003 |
| Citation | Luo Y, et al. (2020) Twist1 promotes dendritic cell-mediated antitumor immunity. Exp Cell Res 392(2):112003 |
| abstractText | Dendritic cells (DCs) play a central role in autoimmunity, immune homeostasis, and presentation of tumor antigens to T cells in order to prime antitumor responses. The number of tumor-infiltrating DCs is associated with survival and prognosis in cancer. Twist1 is a well-known regulator of tumor initiation and promotion, but whether and how DC-derived Twist1 regulates antitumor responses remains poorly understood. Here, we generated a mouse line with Twist1 conditionally depleted in DCs and found that Twist1-deficiency in DCs did not affect the DCs and T cell homeostasis under steady-state conditions; however, in melanoma models, the proportion of conventional DCs (cDCs) in draining lymph nodes (DLNs) was significantly decreased. Accordingly, a decreased ratio and number of tumor-infiltrating cDCs were observed, which reduced the recruitment of tumor-infiltrating T cells. Furthermore, production of IFN-gamma, a crucial antitumor factor, by T cells, was dramatically decreased, which can further dampen the T cell antitumor functions. Collectively, our data indicate that Twist1 in DCs regulates antitumor functions by maintain the number of tumor-infiltrating DCs and T cells, and their antitumor activity. |
