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Allele : Mdm2<tm1Ypz> transformed mouse 3T3 cell double minute 2; targeted mutation 1, Yanping Zhang
Primary Identifier  MGI:3763432 Allele Type  Targeted
Attribute String  Hypomorph Gene  Mdm2
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<b-m2>
Is Recombinase  false Is Wild Type  false
molecularNote  A loxP site flanked neomycin resistance gene cassette was inserted into intron 10 and cystine codon 462 (TGT) in exon 12 was changed to alanine (GCC) (p.C462A). This amino acid substitution abolishes E3 ubiquitin ligase activity without affecting DNA binding ability. The neo cassette was subsequently removed by Cre-mediated recombination.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Mdm2<C462A>,
  • Mdm2<C462A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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