| First Author | Zeng H | Year | 2007 |
| Journal | Mol Endocrinol | Volume | 21 |
| Issue | 11 | Pages | 2795-804 |
| PubMed ID | 17666589 | Mgi Jnum | J:125915 |
| Mgi Id | MGI:3760194 | Doi | 10.1210/me.2007-0048 |
| Citation | Zeng H, et al. (2007) Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior. Mol Endocrinol 21(11):2795-804 |
| abstractText | TRH is a neuropeptide with a variety of hormonal and neurotransmitter/neuromodulator functions. In particular, TRH has pronounced acute antidepressant effects in both humans and animals and has been implicated in the mediation of the effects of other antidepressive therapies. Two G protein-coupled receptors, TRH receptor 1 (TRH-R1) and TRH-R2, have been identified. Here we report the generation and phenotypic characterization of mice deficient in TRH-R1. The TRH-R1 knockout mice have central hypothyroidism and mild hyperglycemia but exhibit normal growth and development and normal body weight and food intake. Behaviorally, the TRH-R1 knockout mice display increased anxiety and depression levels while behaving normally in a number of other aspects examined. These results provide the first direct evidence that the endogenous TRH system is involved in mood regulation, and this function is carried out through TRH-R1-mediated neural pathways. |
