| First Author | Koo JH | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 363 |
| Issue | 2 | Pages | 405-10 |
| PubMed ID | 17884015 | Mgi Jnum | J:127357 |
| Mgi Id | MGI:3763606 | Doi | 10.1016/j.bbrc.2007.08.186 |
| Citation | Koo JH, et al. (2007) Bex1 knock out mice show altered skeletal muscle regeneration. Biochem Biophys Res Commun 363(2):405-10 |
| abstractText | Bex1 and Calmodulin (CaM) are upregulated during skeletal muscle regeneration. We confirm this finding and demonstrate the novel finding that they interact in a calcium-dependent manner. To study the role of Bex1 and its interaction with CaM in skeletal muscle regeneration, we generated Bex1 knock out (Bex1-KO) mice. These mice appeared to develop normally and are fertile, but displayed a functional deficit in exercise performance compared to wild type (WT) mice. After intramuscular injection of cardiotoxin, which causes extensive and reproducible myotrauma followed by recovery, regenerating muscles of Bex1-KO mice exhibited elevated and prolonged cell proliferation, as well as delayed cell differentiation, compared to WT mice. Thus, our results provide the first evidence that Bex1-KO mice show altered muscle regeneration, and allow us to propose that the interaction of Bex1 with Ca(2+)/CaM may be involved in skeletal muscle regeneration. |
