| Primary Identifier | MGI:3764945 | Allele Type | Spontaneous |
| Attribute String | Hypomorph | Gene | Ctnna1 |
| Inheritance Mode | Other (see notes) | Transmission | Germline |
| Strain of Origin | 129S4/SvJae | Is Recombinase | false |
| Is Wild Type | false |
| description | This mutation arose on a APCtm1.1Tno background and leads to a reversion of the tumorogenesis phenotype associated with the APC allele. This reversion only occurs when the two mutant alleles are in cis-configuration. |
| molecularNote | A 4107 bp deletion encompassing exons 3 and 4 occurred in the locus, leading to a frameshift mutation at codon 101. Expression levels of the mutant allele are reduced by two-thirds as measured by RT-PCR analysis, and the protein generated is predicted to not be able to interact with its heterodimer partners. |
