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Allele : Lgr5<tm1(cre/ERT2)Cle> leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Hans Clevers
Primary Identifier  MGI:3764660 Allele Type  Targeted
Attribute String  Inducible, Null/knockout, Recombinase, Reporter Gene  Lgr5
Transmission  Germline Strain of Origin  129P2/OlaHsd
Induced With  tamoxifen Is Recombinase  true
Is Wild Type  false
molecularNote  An EGFP-IRES-creERT2 cassette was inserted into exon 1 of the gene along with a loxP-flanked neomycin cassette. The neomycin gene was then excised in vivo by crossing with cre-deleter strain. GFP expression is driven by the endogenous promoter. Cre expression is induced in Lgr5 expressing cells by tamoxifen treatment.
  • mutations:
  • Insertion
  • synonyms:
  • Lgr5-EGFP,
  • Lgr5-EGFP,
  • Lgr5CREER,
  • Lgr5CREER,
  • Lgr5-cre,
  • Lgr5-cre,
  • Lgr5-creERT,
  • Lgr5-CreERT2-IRES-EGFP,
  • Lgr5<UT>,
  • Lgr5 EGFP-IRES-creERT2,
  • Lgr5-EGFP-IRES-creERT2,
  • Lgr5 EGFP-IRES-creERT2,
  • Lgr5-CreERT2-IRES-EGFP,
  • Lgr5-EGFP-IRES-creERT2,
  • Lgr5<tm1(cre/ESR1)Cle>,
  • Lgr5-creERT,
  • Lgr5<tm1(cre/ESR1)Cle>,
  • Lgr5<UT>
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0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Driven By

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